DelveInsight’s, “Chronic Obstructive Pulmonary Disease Pipeline Insight 2023” report provides comprehensive insights about 70+ companies and 70+ pipeline drugs in the Chronic Obstructive Pulmonary Disease pipeline landscape. It covers the Chronic Obstructive Pulmonary Disease pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Chronic Obstructive Pulmonary Disease pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Key takeaways from the Chronic Obstructive Pulmonary Disease Pipeline Report
Discover the recent breakthroughs and advances in Chronic Obstructive Pulmonary Disease Drug Treatment @ Chronic Obstructive Pulmonary Disease Pipeline Outlook
Recent Developmental Activities in the Chronic Obstructive Pulmonary Disease Treatment Landscape
Chronic Obstructive Pulmonary Disease Pipeline Overview
Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease. It is a poorly reversible lung disease characterized by persistent and progressive airflow limitation caused by an enhanced chronic inflammatory response in the airways and the lungs due to noxious particles or gases. Excessive Smoking is the leading risk factor for COPD. In addition, occupational and environmental exposure to chemical fumes, dust, and other lung irritants accounts for 10–20% of cases. People with a history of severe lung infections in childhood are more likely to develop COPD. Also, α1 antitrypsin deficiency is a rare cause of COPD. The most common symptom of COPD is chronic and progressive dyspnea. Production of cough and sputum is present in up to 30% patient population.
Find out more about chronic obstructive pulmonary disease therapies and drugs @ Chronic obstructive pulmonary disease Treatment Landscape
Chronic Obstructive Pulmonary Disease Emerging Drugs
Benralizumab: AstraZeneca
Benralizumab (FASENRA) is a monoclonal antibody that binds directly to the IL-5 receptor alpha on eosinophil and attracts natural killer cells to induce rapid and near-complete depletion of eosinophil via apoptosis (programmed cell death). The drug is approved by the US FDA for asthma and is currently being developed for other respiratory and immunological disorders such as COPD, atopic dermatitis, and others. The drug was earlier in GALATHEA and TERRANOVA trials (randomized, double-blinded, placebo-controlled, parallel-group trials that assessed the safety and efficacy of Fasenra 30mg and 100mg for preventing COPD exacerbations). At present, the drug is in RESOLUTE (Phase III trial) to evaluate its efficacy and safety.
MV130: Inmunotek S.L.
MV130 (BACTEK) is a bacterial mucosal vaccine or a bacterial polyvalent vaccine in a spray that is administered sublingually to treat recurrent respiratory tract infections in children and adults. MV130 plays a relevant role in modulating the functional activity of the innate and adaptive immune response by stimulating dendritic cells, which are part of innate immunity. A Phase III clinical trial is evaluating MV130 in patients with COPD. At present, the trial is ongoing in Spain.
SB-240563: GlaxoSmithKline
SB-240563 (mepolizumab) is a humanized monoclonal antibody that blocks human interleukin 5 (hIL-5) from binding to its receptor. Initial clinical studies investigated the safety and efficacy of SB-240563 for the treatment of asthma and atopic dermatitis (AD). SB-240563 reduced peripheral and tissue eosinophils in patients with asthma and healthy volunteers. Currently, it is in the Phase III stage of the clinical trials.
SAR440340: Sanofi/Regeneron
SAR440340 (Itepekimab) is a humanized IgG4P monoclonal antibody that blocks human interleukin 33 (hIL-33) from binding to its receptor. IL-33 is an epithelial cytokine that initiates and amplifies innate and adaptive type 2 and 1 inflammatory pathways in response to epithelial insults due to exposure to allergens, viruses, cigarette smoke, and pollutants. SAR440340 was invented using Regeneron’s proprietary VelocImmune technology that yields optimized fully-human antibodies and is being developed jointly by Regeneron and Sanofi as part of a global collaboration agreement.
CHF 6001: Chiesi Farmaceutici S.p.A.
CHF6001 is a novel inhaled phosphodiesterase-4 (PDE-4) inhibitor developed as an extrafine formulation (i.e., with mass median aerodynamic diameter ≤ 2 μm) and low systemic exposure. This allows CHF6001 to reach a therapeutic concentration in the target organ, the lung, with reduced systemic exposure, limiting systemic adverse effects. The drug is administered through a dry powder inhaler (DPI NEXThaler).
YPL 001: Yungjin Pharm. Co., Ltd.
YPL 001 is a drug molecule that belongs to the anti-inflammatory and anti-histamine class of drugs. The drug is being developed for COPD. YPL-001 is a product developed using wild chives, which grow naturally in nature, as a raw material. A Phase II trial was conducted in US hospitals to assess the drug’s safety in patients with moderate-to-severe COPD. In Phase I studies, YPL-001 was well tolerated in healthy subjects following single (up to 320 mg) and multiple (up to 240 mg twice daily [BID]) oral doses with no serious adverse events (AEs).
Chronic Obstructive Pulmonary Disease Therapeutics Assessment
There are approx. 70+ key companies which are developing the therapies for Chronic Obstructive Pulmonary Disease. The companies which have their Chronic Obstructive Pulmonary Disease drug candidates in the most advanced stage, i.e. Phase III include, AstraZeneca.
Learn more about the novel and emerging Chronic Obstructive Pulmonary Disease pipeline therapies and companies @ Chronic Obstructive Pulmonary Disease Ongoing Clinical Trials
Chronic Obstructive Pulmonary Disease Segmentation
The Chronic Obstructive Pulmonary Disease Pipeline report proffers an integral view of the Chronic Obstructive Pulmonary Disease emerging novel therapies segmented by Stage, Product Type, Molecule Type, Mechanism of Action, and Route of Administration.
Scope of the Chronic Obstructive Pulmonary Disease Pipeline Report
Table of Content
Dive deep into rich insights into new Chronic Obstructive Pulmonary Disease Drugs, visit @ Chronic Obstructive Pulmonary Disease Key Companies and Pipeline Therapies
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